Academic appointment details

  • Director, Monash Cardiovascular Research Centre
  • Associate Director, MonashHeart, Monash Health
  • Adjunct Professor of Medicine, School of Clinical Sciences at Monash Health, Monash University

Academic address

Monash Cardiovascular Research Centre
MonashHeart
Monash Medical Centre
246 Clayton Road, Clayton
Victoria Australia 3168

Academic contact details

Phone: +61 3 9594 2243
Fax: +61 3 9594 6939

Summary of qualifications, experience and current interests

Professor James D. Cameron MBBS, MD, BE(Elec), MEngSc, FIEAust., CPE(Biomed), FCSANZ

James Cameron completed undergraduate degrees in Engineering and Medicine at Melbourne University before going on to post-graduate research degrees in Biomedical Engineering and Medicine. From 1992-2001 he was Senior Lecturer (Biomedical Engineering) at La Trobe University and Senior Clinical Associate at The Baker Heart Research Institute. Subsequently, as Associate Professor at both La Trobe University (Biomedical Engineering) and (honorary) in the Department of Medicine, Monash University, he accepted a senior medical staff appointment at Southern Health (the largest government health network in the state of Victoria) and re-located clinical research activities to both the Department of Vascular Sciences and Medicine as Director of Research and Training, and to MonashHeart (the Cardiology service of Southern Health).

In 2007 he was appointed to the position of Associate Director (Research & Education) of MonashHeart and Adjunct Professor of Medicine at Monash University. In the same year he was appointed to a chair in biomedical engineering at La Trobe University.

In 2012 research activities were concentrated at MonashHeart where Professor Cameron remains Director of the Monash Cardiovascular Research Centre and, in 2014, assumed the position of Associate Director of MonashHeart. He continues in that role currently and maintains senior medical staff appointment with MonashHeart and in the private sector at Epworth Health Care with the Epworth HospitalCheck unit.

Professor Cameron is internationally known for his work on large, conduit artery function and mechanics, in particular in the development of assessment techniques to investigate mechanisms of arterial disease, the role of arterial stiffness in risk-assessment and its use in identification of pre-clinical states. His early work provided some of the first evidence that arterial function is modifiable and therefore a potential therapeutic target. Current research interests include non-invasive assessment of arterial mechanical properties as they relate to cardiovascular risk and clinical management, with a particular interest in assessment of arterial stiffness in relation to vascular health and biological ageing and the potential for therapeutic intervention.

In 2004 he was co-recipient of the 2004 RJ Hall prize of the Cardiac Society of Australia and New Zealand (CSANZ) and was admitted to Fellowship of CSANZ in 2006. Currently he is Vice-President of The International Society for Vascular Health (ISVH) and Chairman of the Australasian Regional Committee of the ISVH.

Publications

Professor Cameron is author or co-author of over 120 peer-reviewed scientific publications, five invited book chapters, as well as numerous invited editorials and commentaries in high-impact journals. Papers published in the previous six years have been cited more than 450 times (average number of citations per paper > 13). Professor Cameron is regularly invited to speak on arterial structure, function and cardiovascular risk at international meetings. He is a member of the editorial board of the AHA journal Hypertension, the Journal of Hypertension, one of only two Australians to be on the leading American and European journals in the firld of hypertension.

Fostering Clinical Research Training and Career Development

Professor Cameron has supervised many PhD (and Masters students) who have gone on to post-doctorial and industry positions. He currently supervises five PhD students (engineering, medical and nursing) and mentors recently qualified clinicians and scientists in their transition to independent clinical researchers.

Translation of Clinical Research Findings into Improved Healthcare

Professor Cameron acts as principle investigator in a number of pharmaceutical industry studies and was national co-coordinator of the STRADIVARIUS and AQUARIUS studies, international, multicentre studies employing intravascular ultrasound to assess coronary plaque regression.  He has developed clinical laboratory systems used extensively for assessment of arterial properties in Australia and overseas. The arterial assessment techniques he has developed have provided important evidence demonstrating the concept of the systemic arterial stiffness as a valid therapeutic target.

Professional qualifications

Qualifications – Melbourne University

  • Bachelor of Engineering (Electrical)  B.E.(Hons) 1975
  • Master of Engineering Science (Research)  M.Eng.Sc. 1977
  • Bachelor of Medicine, Bachelor of Surgery M.B. B.S. 1981
  • Doctor of Medicine M.D. 1996

Qualifications

  • Level 2 SCCT 2008

Professional registrations

  • Registered medical practitioner, Australia.
  • Registered medical practitioner, United Kingdom.
  • Charted Professional Engineer (Biomedical) – National Professional Engineers Register – level 3 (Biomedical).
  • Fellow Cardiac Society of Australia & New Zealand.

Scientific and professional societies

  • Fellow of the Cardiac Society of Australia and New Zealand.
  • Fellow, Institute of Engineers (Australia) and Member, College of Biomedical Engineers, IE(Aust.).
  • Member High Blood Pressure Research Council of Australia
  • President, International Society for Vascular Health.
  • Chair, Australasian Regional Committee of The International Society for Vascular Health.
Current appointments
  • Director, Monash Cardiovascular Research Centre and Associate Director MonashHeart. Monash Health
  • Adjunct Professor of Medicine, School of Clinical Sciences at Monash Health, Monash University
  • Member, Senior Medical Staff, Monash Health, MonashHeart (Cardiology),  Monash Medical Centre, Melbourne, Australia
Awards and honours
  • Joint recipient RT Hall prize of the Cardiac Society of Australia and New Zealand 2004
Committee memberships
  • 2010-2011: President, The International Society for Vascular Health. (2005-2009: International Vice-President)
  • Past Chairman, Australasian Regional Committee, The International Society for Vascular Health
Research interests

Main research endeavours include:

  • Large conduit artery function and mechanics, in particular the development of assessment techniques to investigate mechanisms of arterial disease, the role of arterial stiffness in risk-assessment and its use in identification of pre-clinical states
  • Non-invasive assessment of arterial mechanical properties as they relate to cardiovascular risk and clinical management
  • Assessment of arterial stiffness in relation to vascular health and biological ageing and the potential for therapeutic intervention
Publications

Theses
Cameron JD. Systemic Arterial Compliance and Its Association With Aerobic Fitness and Coronary Artery Disease. Doctor of Medicine, Monash University. 1996
Cameron JD. Patterns of Acceleration in Human Limb Movement. Master of Engineering Science, University of Melbourne. 1977

Recent Publications

  1. Akalanli C, Tay D, Cameron JD. Optimization of a generalized radial-aortic transfer function using parametric techniques. Computers in Biology and Medicine. 2016;206-213
  2. Adams D B, Narayan O, Munnur RK, Cameron JD, Wong DTL, Talman AH, Harper RW, Seneviratne SK, Meredith IT, Ko BS. Ethnic differences in coronary plaque and epicardial fat volume quantified using computed tomography. International Journal of Cardiovascular Imaging. 2016;1-9
  3. BoganaShanmugam V, Psaltis PJ, Wong DT, Seneviratne S, Cameron JD, Meredith IT, Malaiapan Y. Chronic Total Occlusion – Percutaneous Coronary Intervention (CTO-PCI) Experience in a Single, Multi-operator Australian Centre: Need for dedicated CTO-PCI programs. Heart Lung and Circulation. 2016; 7:676-682
  4. Ko BS, Seneviratne S, Cameron JD, Gutman S, Crossett M, Munnur K, Meredith IT, Wong DTL. Rest and stress transluminal attenuation gradient and contrast opacification difference for detection of hemodynamically significant stenoses in patients with suspected coronary artery disease. International Journal of Cardiovascular Imaging. 2016;7:1131-1141
  5. Ko BS, Wong DTL, Nørgaard BL, Leong DP, Cameron JD, Gaur S, Marwan M, Achenbach S, Kuribayashi S, Kimura T, Meredith IT, Seneviratne SK. Diagnostic performance of transluminal attenuation gradient and noninvasive fractional flow reserve derived from 320-detector row CT angiography to diagnose hemodynamically significant coronary stenosis: An NXT substudy. Radiology. 2016;1:75-83
  6. Psaltis PJ, Talman AH, Munnur K, Cameron JD, Ko BSH, Meredith IT, Seneviratne SK, Wong DTL. Relationship between epicardial fat and quantitative coronary artery plaque progression: insights from computer tomography coronary angiography. International Journal of Cardiovascular Imaging. 2016;2:317-328
  7. Nasis A, Meredith IT, Cameron JD, Seneviratne SK. Coronary computed tomography angiography for the assessment of chest pain: current status and future directions. International Journal of Cardiovascular Imaging. 2015;125-143
  8. Gooley R, Cameron JD, Meredith IT. Transcatheter Aortic Valve Implantation – Yesterday, Today and Tomorrow. Heart Lung and Circulation. 2015;12:1149-1161
  9. Narayan O, Leung MCH, Wong DTL, Meredith IT, Cameron JD. Percutaneous Coronary Intervention Enhances Accelerative Wave Intensity in Coronary Arteries. PLoS ONE. 2015;12(e0142998):e0142998
  10. Gooley RP, Cameron JD , Soon J, Loi D, Chitale G, Syeda R, Meredith IT. Quantification of normative ranges and baseline predictors of aortoventricular interface dimensions using multi-detector computed tomographic imaging in patients without aortic valve disease. European Journal of Radiology. 2015;9:1737-1744
  11. Wong DTL, Narayan O, Leong DP, Bertaso AG, Maia MG, Ko BSH, Baillie T, Seneviratne SK, Worthley MI, Meredith IT, Cameron JD. Regional aortic distensibility and its relationship with age and aortic stenosis: a computed tomography study. International Journal of Cardiovascular Imaging. 2015;5:1053-1062
  12. Cameron JD. Carotid structure and flow relationship: A potential but unproven prognostic index. Journal of Hypertension. 2015;10:2016-2017
  13. Narayan O, Dart A, Meredith IT, Cameron JD. Reply. Journal of Hypertension. 2015;1:188-189
  14. Gooley RP, Cameron JD, Meredith IT. Assessment of the geometric interaction between the lotus transcatheter aortic valve prosthesis and the native ventricular aortic interface by 320-multidetector computed tomography. JACC: Cardiovascular Interventions. 2015;5:740-749
  15. Gooley RP, Talman AH, Cameron JD ,Lockwood SM, Meredith IT. Comparison of Self-Expanding and Mechanically Expanded Transcatheter Aortic Valve Prostheses. JACC: Cardiovascular Interventions. 2015;7(1988):962-971
  16. Narayan O, Davies JE, Hughes AD, Dart AM, Parker KH, Reid C, Cameron JD. Central aortic reservoir-wave analysis improves prediction of cardiovascular events in elderly hypertensives. Hypertension. 2015;3:629-635
  17. Wong DTL , Narayan O, Ko BSH, Leong DP, Seneviratne S, Potter EL, Cameron JD, Meredith IT, Malaiapan Y. A novel coronary angiography index (DILEMMA score) for prediction of functionally significant coronary artery stenoses assessed by fractional flow reserve: A novel coronary angiography index. American Heart Journal. 2015;4:564-571.e4
Higher degree by supervision

Ph.D. Monash University (Faculty of Medicine, Nursing & Health Sciences)

2014 – Present.  Dr Kiran Munnur: Longitudinal Assessment of Coronary Plaque using Computed Coronary Tomography, Intravascular Ultrasound and Optical Coherence Tomography.

2012 – Present.  Dr Robert Gooley: A Systems Approach to the Function of the Left Ventriclar Outflow Tract – Aortic Valve Complex and the Impact of Trans Catheter Aortic Valve Implantation.

2012 – Present.  Dr Om Narayan: In-vivo Studies on Vasculo-Vascular Coupling and the Role of Aortic Pressure Wave Morphology on Coronary Blood Flow.

2012 – Present.  Dr Siobhan Lockwood. Multi-modality Assessment of the Aortic Root and Ascending Aorta – Implications for the Diagnosis and Treatment of Cardiac Disease.

2011 – Present.  Dr Arthur Nasis: Use of Novel Imaging Techniques for the Diagnosis of Coronary Artery Disease and Myocardial Ischaemia: Implications for the Assessment of Patients with Chest Pain.

2010 – 2013.  Dr Brian Ko. Stress Myocardial Perfusion Imaging Using Computed Tomography in Stable Coronary Artery Disease.

2009 – 2014.  Dr Adam Hutchison: The MonAMI 12-lead Field Triage of STEMI Patients Project.

2007 – 2013.  Ms Cathy Martin: Differences in Arterial and Autonomic Function in Individuals with Established, Office- and Masked-hypertension. Co-supervision with Prof B McGrath.

2002 – 2006.  Dr Michael Leung: Insights into the Human Coronary Microvasculature – The influence of Aortic Mechanical Properties and Coronary Artery Disease. Co-supervision with Prof I Meredith.

2002 – 2003.  Dr Sarah Hope. Arterial Pressure Waves: Waveform Characteristics, their Associations and Factors Influencing Propagation. Co-supervision with Prof I Meredith.

Ph.D. La Trobe University (Faculty of Science, Technology & Engineering)

2009 – Present Cagla Akalanli. Optimization of a Generalised Radio-Aortic Transfer Function Using Parametric Techniques.

2002 – 2007.  Dr Anil Samuel. A wavelet based approach to boundary detection in coronary arteries.

1996 – 2001.  Dr Silvia Gong.

1995 – 2001.  Dr Joe Vartouli (Part-time candidature). Design, Development and Clinical Validation of a System for Measuring Cardiac Output in Patients Undergoing General Anaethesia using Nitrous Oxide

1993 – 1996.  Dr Jannine Vandenberg. An Investigation of a System for the Automatic Classification and Quantification of Tissue Types Imaged Using Intravascular Ultrasound.

Bachelor of Medical Science Honours Project (Faculty of Medicine, Nursing & Health Sciences)

2014  Mr Marcus Kok. Use of Echocardiography and Cardiac CT in Assessment of the Left Atrial Appendage.

2014  Jonathan TK Lee. Resident Vascular Progenitor Cells and PDGRF-Alfa. (Co-supervisoer Dr Jason Kovacic Cardiovascular Research Centre, Icahn School of Medicine at Mount Sinai, New York, USA)

2008   Mr Josh Casan. Relationship of Cardiac Computerised Tomographic Assessment of Ascending Aortic Strain and Non-Invasive Assessment of Aortic Mechanical Function

2008  Ms Lee-Jen Luu: The Effect of Clopidogrel on Endothelial Function.

2007  Mr Kevin Cheng: The Relative Contribution of Left Ventricular Systolic Myocardial Motion, Arterial Mechanical Properties, and Endothelial Function to Arterial Pressure waveform Morphology.